Effect of Ag⁺ on isolated bullfrog gastric mucosa

In nitrate solutions, Ag+ added to the luminal side had marked effects on transmucosal conductance and potential difference (PD). Conductance increased quickly (85% within 60 s, 420% by 10 min); PD increased initially (11% within 30 s) and then fell precipitously (58% decreased within 2 min, 85% decreased by 10 min). During this period, no increase in mannitol permeability was found. These changes were essentially similar in …