Retinoic acid selectively inhibits il-5 receptor expression during progenitor cell differentiation

Retinoids, a class of compounds related to vitamin A, have profound effects on hematopoiesis. We have previously shown that all-trans retinoic acid (ATRA) inhibits eosinophil-basophil differentiation but not neutrophil differentiation in vitro. Whether this effect is mediated through the interleukin-5 receptor (IL-5R) or through another mechanism remains unclear. Hence, we examined the effect of ATRA (10s to 1Q-8M) on purified CD34+ cord blood …