Journal article
XRCC4's interaction with XLF is required for coding (but not signal) end joining
Abstract
XRCC4 and XLF are structurally related proteins important for DNA Ligase IV function. XRCC4 forms a tight complex with DNA Ligase IV while XLF interacts directly with XRCC4. Both XRCC4 and XLF form homodimers that can polymerize as heterotypic filaments independently of DNA Ligase IV. Emerging structural and in vitro biochemical data suggest that XRCC4 and XLF together generate a filamentous structure that promotes bridging between DNA …
Authors
Roy S; Andres SN; Vergnes A; Neal JA; Xu Y; Yu Y; Lees-Miller SP; Junop M; Modesti M; Meek K
Journal
Nucleic Acids Research, Vol. 40, No. 4, pp. 1684–1694
Publisher
Oxford University Press (OUP)
Publication Date
February 1, 2012
DOI
10.1093/nar/gkr1315
ISSN
0305-1048