Association of α4β2 nicotinic receptor and heavy smoking in schizophrenia

Abstract

INTRODUCTION: Previously we suggested that the CHRNA7 polymorphism in nicotinic receptor genes, in particular the D15S1360 in CHRNA7, is associated with smoking in schizophrenia. Schizophrenia patients are usually heavy smokers. In this study we hypothesized that high-affinity nicotinic receptors are associated with smoking in such patients. OBJECTIVE: To investigate the role of alpha4 (Ch 20) and beta2 (Ch 1) genes in conferring a risk for …

Authors

Voineskos S; De Luca V; Mensah A; Vincent JB; Potapova N; Kennedy JL

Journal

Journal of Psychiatry and Neuroscience, Vol. 32, No. 6, pp. 412–416

Publication Date

November 2007

DOI

10.1503/jpn.0740

ISSN

1180-4882

Associated Experts

Sophocles Voineskos

Assistant Professor (Part-Time), Faculty of Health Sciences

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