Journal article
PML has a predictive role in tumor cell permissiveness to interferon-sensitive oncolytic viruses
Abstract
The oncotropic phenotypes of several viruses correlate with tumor-associated deficiencies within interferon (IFN) signaling pathways. This observation formed the conceptual basis for developing oncolytic viruses deleted for viral proteins that inhibit the host IFN-dependent antiviral response, such as herpes simplex virus type-1 infected cell protein-0 (ICP0) and vesicular stomatitis virus matrix protein. Many viruses have evolved means to …
Authors
Sobol PT; Hummel JL; Rodrigues RM; Mossman KL
Journal
Gene Therapy, Vol. 16, No. 9, pp. 1077–1087
Publisher
Springer Nature
Publication Date
9 2009
DOI
10.1038/gt.2009.68
ISSN
0969-7128
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Biomarkers, TumorHumansImmediate-Early ProteinsInterferon-alphaNeoplasmsNuclear ProteinsOncolytic VirotherapyOncolytic VirusesPromyelocytic Leukemia ProteinReceptors, Retinoic AcidRetinoic Acid Receptor alphaSimplexvirusTranscription FactorsTumor Cells, CulturedTumor Suppressor ProteinsUbiquitin-Protein LigasesVesicular stomatitis Indiana virusViral Tropism