Hormone Therapies and Menopause: Where Do We Stand in the Post-WHI Era?

The WHI study, its premature termination, and controversy over its findings have motivated patientsand physicians alike to seek lower-dose therapies for menopausal symptoms. Substantial data indicate that low-dose ET/EPT is effective in treating osteoporosis, hot flushes, vulvaginal dryness anditching, and sleeping difficulties. Furthermore, low-dose therapies are associated with a decrease inbreast tenderness compared to standard dose …