Prenatal Exposure to Antidepressants and Persistent Pulmonary Hypertension of the Newborn

ABSTRACT Decisions about using antidepressants to treat major depressive disorder during pregnancy are complex. A potential adverse effect is persistent pulmonary hypertension of the newborn (PPHN), with an estimated baseline prevalence of 1.9 of 1000 live births. Symptoms can range from mild respiratory distress to hypoxia. Although a potential association between maternal use of selective serotonin reuptake inhibitors (SSRIs) during pregnancy …