Preventive treatment of patients after non-disabling cerebral ischaemia of presumed arterial origin; comparative randomized study with intensive anticoagulant therapy or aspirin treatment

Objective. Because aspirin is ischaemia, the efficacy in the secondary prevention after cerebral ischaemia, the efficacy and safety of 30 mg aspirin daily and oral anticoagulation (international normalized ration (INR): 3.0- 4.5) was studied in the Stroke prevention in reversible ischaemia trial (SPIRIT). Design. Open, randomised, controlled study. Setting. 58 hospitals: 52 in the Netherlands and 6 in other countries. Methods. Patients referred …