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Ion occupancy of the channel pore is critical for...

Journal article

Ion occupancy of the channel pore is critical for triggering excitation-transcription (ET) coupling

Abstract

During membrane depolarization the voltage-gated calcium channel (VGCC) activates gene expression in excitable cells by means of a signal-transduction pathway termed excitation transcription (ET) coupling. The L-type calcium channel Cav1.2 can drive nuclear activity by either the ERK-CREB pathway, the Ca²⁺/calmodulin-dependent protein kinase II (CaMKII) cascade, or via the Ca²⁺-dependent protein phosphatase calcineurin. The ERK-CREB pathway …

Authors

Servili E; Trus M; Atlas D

Journal

Cell Calcium, Vol. 84, ,

Publisher

Elsevier

Publication Date

December 2019

DOI

10.1016/j.ceca.2019.102102

ISSN

0143-4160

Associated Experts

Michael Trus

Associate Professor (Part-Time), Faculty of Health Sciences

Labels

Fields of Research (FoR)

3208 Medical physiology 32 Biomedical and Clinical Sciences 3101 Biochemistry and cell biology

Medical Subject Headings (MeSH)

Calcineurin Calcium Calcium Channels, L-Type Calcium Signaling Calcium-Calmodulin-Dependent Protein Kinase Type 2 Calmodulin Excitation Contraction Coupling HEK293 Cells Humans Ions Lanthanum MAP Kinase Signaling System Membrane Potentials Structure-Activity Relationship Transcriptional Activation

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