Journal article
Alpha-2-macroglobulin may provide protection from thromboembolic events in antithrombin III-deficient children
Abstract
Antithrombin III (ATIII) deficiency has been implicated in adults as a predisposing factor to thrombosis; however, thromboembolic complications are rare in children with the same deficiency. We hypothesized that because of the elevated levels of plasma alpha-2- macroglobulin (alpha 2M) throughout childhood, plasmas of ATIII- deficient children inhibit thrombin more efficiently than those of ATIII-deficient adults. In total, 14 ATIII-deficient …
Authors
Mitchell L; Piovella F; Ofosu F; Andrew M
Journal
Blood, Vol. 78, No. 9, pp. 2299–2304
Publisher
American Society of Hematology
Publication Date
November 1, 1991
DOI
10.1182/blood.v78.9.2299.bloodjournal7892299
ISSN
0006-4971