This chapter contains sections titled: Introduction Questions Literature‐search strategy and results What is the role of anthracycline or anthracenedione‐based chemotherapy in adults with newly diagnosed or relapsed MCL? What is the role of rituximab (as a single agent, in combination with chemotherapy) in adults with newly diagnosed or relapsed MCL? What is the role of high dose chemotherapy and stem cell transplantation in patients with newly diagnosed or relapsed MCL? References Appendix Introduction Questions Literature‐search strategy and results What is the role of anthracycline or anthracenedione‐based chemotherapy in adults with newly diagnosed or relapsed MCL? What is the role of rituximab (as a single agent, in combination with chemotherapy) in adults with newly diagnosed or relapsed MCL? What is the role of high dose chemotherapy and stem cell transplantation in patients with newly diagnosed or relapsed MCL? References Appendix