Heparin-induced thrombocytopenia

Heparin (HP)-induced thrombocytopenia (HIT) is an unusual immune-mediated adverse drug reaction with the central paradox being its strong association with thrombosis, despite the role of an anticoagulant (heparin) in causing a fall in platelet count. Platelet factor 4 (PF4) bound to endothelial surface heparan sulfate (HS) can be recognized by HIT antibodies, potentially causing endothelial cell activation, with procoagulant consequences. …