Journal article
Bleeding Risk in Atrial Fibrillation Patients Taking Vitamin K Antagonists: Systematic Review and Meta‐Analysis
Abstract
Vitamin K antagonists (VKAs) prevent stroke in atrial fibrillation (AF) at the cost of bleeding risk. To determine major bleeding rates in AF patients, we conducted a systematic review that identified 51 eligible studies including more than 342,699 patients. The pooled estimate of the rate of major bleeding was 2.51 (99% confidence interval: 2.03-3.11) bleeds per 100 patient-years. The results represent the best estimates of bleeding risk that …
Authors
Lopes LC; Spencer FA; Neumann I; Ventresca M; Ebrahim S; Zhou Q; Bhatnaga N; Schulman S; Eikelboom J; Guyatt G
Journal
Clinical Pharmacology & Therapeutics, Vol. 94, No. 3, pp. 367–375
Publisher
Wiley
Publication Date
9 2013
DOI
10.1038/clpt.2013.99
ISSN
0009-9236