A Systematic Review of Reviews to Examine the Association Between Hypertension and Cognitive Impairments in Adults

Background: Essential hypertension is thought to be a risk factor for cognitive impairment. Researchers have proposed several explanations for this link, including endothelial dysfunction/vascular dysregulation, white matter disease, the renin–angiotensin system and inhibition of acetylcholine release by angiotensin II, strategic strokes or tissue loss with strokes, or abnormal insulin signaling. We conducted a review of reviews to investigate …