Febrile and Allergic Transfusion Reactions

Febrile and allergic reactions are the most common adverse events associated with the transfusion of blood components. Most febrile reactions are caused by biological response modifiers that accumulate in the component during storage or are the result of leucocyte antigenantibody reactions. Leucocyte reduction of blood components has decreased the frequency of these reactions; however, when they do occur the challenge for the clinician is to …