Guidance for designing and analysing observational studies: The strengthening analytical thinking for observational studies (STRATOS) initiative

Observational studies pose a number of biostatistical challenges. Methodological approaches have grown exponentially, but most are rarely applied in the real world. The STRengthening Analytical Thinking for Observational Studies (STRATOS) initiative is an international collaboration that was formed to provide guidance to help bridge the gap between methodological innovation and application. STRATOS is focused on identi-fying issues and …