Peripheral intravenous infusion of potassium chloride: Effect of solution composition on infusion-site pain

Objective: To test the hypothesis that pain at the site of peripheral intravenous infusion is greater if potassium chloride is administered in sterile water than if it is administered in saline. Methods: A randomized, double-blind study of infusion-site pain was completed with 36 hospital inpatients with hypokalemia who required 1, 2, or 3 peripheral intravenous infusions of potassium chloride (10 mmol) in 100 mL of IV fluid. Patients were …