Effect of Trimebutine on Postprandial Colonic Motor Activity in Healthy Subjects and Patients with Irritable Bowel Syndrome

We examined the effect of orally administered trimebutine maleate (200 mg) on postprandial motor activity measured manometrically in the sigmoid colon of 11 healthy subjects and nine patients with constipation‐predominant irritable bowel syndrome (IBS) in a double‐blind, placebo·controlled trial. Eight normal subjects showed increased motor activity following the meal after placebo, with a mean increase of 21.9%± 4.5%. Seven IBS patients showed …