Journal article
Bradykinin stimulates endothelial cell fatty acid oxidation by CaMKK-dependent activation of AMPK
Abstract
Endothelial cell lipotoxicity mediated by accumulation of free fatty acids is an early event in the pathogenesis of atherosclerosis. The energy-sensor AMP-activated protein kinase (AMPK) is a key regulator of endothelial cell lipid metabolism. To test the hypothesis that bradykinin (BK) regulates AMPK and fatty acid oxidation in endothelium, stimulations of bovine aortic endothelial cells (BAECs) with bradykinin were performed. BK stimulation …
Authors
Mount PF; Lane N; Venkatesan S; Steinberg GR; Fraser SA; Kemp BE; Power DA
Journal
Atherosclerosis, Vol. 200, No. 1, pp. 28–36
Publisher
Elsevier
Publication Date
9 2008
DOI
10.1016/j.atherosclerosis.2007.12.003
ISSN
0021-9150