Journal article
Conversion of Low Density Lipoprotein-associated Phosphatidylcholine to Triacylglycerol by Primary Hepatocytes*
Abstract
We have studied the uptake and metabolism of phosphatidylcholine (PC), the major phospholipid of low density lipoproteins (LDL), by cultures of primary hepatocytes. Strikingly, in the absence of the LDL receptor, PC incorporation into hepatocytes was inhibited by only 30%, whereas cholesteryl ether uptake was inhibited by 60-70%. On the other hand, scavenger receptor class B, type I, the other important receptor for LDL in the liver, was found …
Authors
Minahk C; Kim K-W; Nelson R; Trigatti B; Lehner R; Vance DE
Journal
Journal of Biological Chemistry, Vol. 283, No. 10, pp. 6449–6458
Publisher
Elsevier
Publication Date
March 2008
DOI
10.1074/jbc.m706995200
ISSN
0021-9258
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AcylationAnimalsApolipoprotein B-100Bridged-Ring CompoundsCell LineCholesterol EstersCholesterol, LDLCrotalid VenomsDiacylglycerol O-AcyltransferaseEnzyme ActivationHepatocytesLiverLysosomesMiceNorbornanesPhosphatidylcholinesPhosphodiesterase InhibitorsReceptors, LDLScavenger Receptors, Class BThiocarbamatesThionesTriglyceridesType C Phospholipases