Journal article
Butein impairs the protumorigenic activity of malignant pleural mesothelioma cells
Abstract
Chronic inflammation appears to be a driving force behind cancer progression. NFκB and STAT3 activation plays a pertinent role in this process by mediating chemoresistance and the acquisition of mesenchymal features of protumorigenic cells. Epidemiological data and experimental observations suggest that Malignant Pleural Mesothelioma (MPM) is a prototype of chronic inflammation-driven cancer. Chemoresistance is a major feature of MPM. Thus, …
Authors
Cioce M; Canino C; Pulito C; Muti P; Strano S; Blandino G
Journal
Cell Cycle, Vol. 11, No. 1, pp. 132–140
Publisher
Taylor & Francis
Publication Date
1 2012
DOI
10.4161/cc.11.1.18474
ISSN
1538-4101
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsAntineoplastic AgentsCell Line, TumorCell Transformation, NeoplasticChalconesDown-RegulationGlutamatesGuanineHumansIntercellular Adhesion Molecule-1Interleukin-6Interleukin-8Matrix Metalloproteinase 9MesotheliomaMiceMice, NudeNF-kappa BPemetrexedPhosphorylationPleural NeoplasmsSTAT3 Transcription FactorTransplantation, HeterologousTwist-Related Protein 1Vascular Endothelial Growth Factor AVimentin