Journal article
Transcriptional Regulation by Mutant p53 and Oncogenesis
Abstract
More than half of all human cancers carry p53 gene mutations whose resulting proteins are mostly full-length with a single aminoacid change, abundantly present in cancer cells and unable to exert oncosuppressor activities. Frequently, mutant p53 proteins gain oncogenic functions through which they actively contribute to the establishment, the maintenance and the spreading of a given cancer cell. Intense research effort has been devoted to the …
Authors
Santoro R; Strano S; Blandino G
Journal
Subcellular Biochemistry, Vol. 85, , pp. 91–103
Publisher
Springer Nature
Publication Date
2014
DOI
10.1007/978-94-017-9211-0_5
ISSN
0306-0225