Journal article
Canadian Multicenter Project on Standardization of Programmed Death-Ligand 1 Immunohistochemistry 22C3 Laboratory-Developed Tests for Pembrolizumab Therapy in NSCLC
Abstract
INTRODUCTION: The programmed death-ligand 1 (PD-L1) immunohistochemistry (IHC) assay is used to select patients for first or second-line pembrolizumab monotherapy in NSCLC. The PD-L1 IHC 22C3 pharmDx assay requires an Autostainer Link 48 instrument. Laboratories without this stainer have the option to develop a highly accurate 22C3 IHC laboratory-developed test (LDT) on other instruments. The Canadian 22C3 IHC LDT validation project was …
Authors
Torlakovic E; Albadine R; Bigras G; Boag A; Bojarski A; Cabanero M; Camilleri-Broët S; Cheung C; Couture C; Craddock KJ
Journal
Journal of Thoracic Oncology, Vol. 15, No. 8, pp. 1328–1337
Publisher
Elsevier
Publication Date
August 2020
DOI
10.1016/j.jtho.2020.03.029
ISSN
1556-0864