Journal article
Nitrous oxide (N2O) and subsequent open-label SSRI treatment of adolescents with depression (NOTAD): study protocol for a randomised controlled trial
Abstract
BackgroundThe first line of pharmacological treatment for severe depressive disorders in young people is selective serotonin reuptake inhibitors (SSRIs). However, beneficial clinical effects are rarely observed before several weeks into treatment. Nitrous oxide (N2O) has a long-standing safety record for pain relief and has been used in adults and young people. In adults with severe treatment-resistant depression, a single dose of N2O had …
Authors
Stewart RM; Wong JWY; Runions KC; Rao P; Moore JK; Davies SR; von Ungern-Sternberg BS; Sommerfield D; Zepf FD
Journal
Trials, Vol. 18, No. 1,
Publisher
Springer Nature
Publication Date
December 2017
DOI
10.1186/s13063-017-2342-4
ISSN
1468-6708