Journal article
Mimicking the human environment in mice reveals that inhibiting biotin biosynthesis is effective against antibiotic-resistant pathogens
Abstract
To revitalize the antibiotic pipeline, it is critical to identify and validate new antimicrobial targets1. In Mycobacteria tuberculosis and Francisella tularensis, biotin biosynthesis is a key fitness determinant during infection2–5, making it a high-priority target. However, biotin biosynthesis has been overlooked for priority pathogens such as Acinetobacter baumannii, Klebsiella pneumoniae and Pseudomonas aeruginosa. This can be attributed to …
Authors
Carfrae LA; MacNair CR; Brown CM; Tsai CN; Weber BS; Zlitni S; Rao VN; Chun J; Junop MS; Coombes BK
Journal
Nature Microbiology, Vol. 5, No. 1, pp. 93–101
Publisher
Springer Nature
Publication Date
January 2020
DOI
10.1038/s41564-019-0595-2
ISSN
2058-5276