Journal article
The caveolin-1 regulated protein follistatin protects against diabetic kidney disease
Abstract
Glomerular matrix protein accumulation, mediated largely by mesangial cells, is central to the pathogenesis of diabetic kidney disease. Our previous studies showed that the membrane microdomains caveolae and their marker protein caveolin-1 regulate matrix protein synthesis in mesangial cells in response to diabetogenic stimuli, and that caveolin-1 knockout mice are protected against diabetic kidney disease. In a screen to identify the molecular …
Authors
Zhang D; Gava AL; Van Krieken R; Mehta N; Li R; Gao B; Desjardins EM; Steinberg GR; Hawke T; Krepinsky JC
Journal
Kidney International, Vol. 96, No. 5, pp. 1134–1149
Publisher
Elsevier
Publication Date
11 2019
DOI
10.1016/j.kint.2019.05.032
ISSN
0085-2538