Journal article
Targeting mutant p53 in cancer: the latest insights
Abstract
This commentary wishes to highlight the latest discoveries in the mutant p53 field that have been discussed in the 8th p53 Mutant Workshop 2019, held in Lyon. TP53 mutant (mutp53) proteins are involved in the pathogenesis of most human cancers. Mutp53 proteins not only lose wild-typ53 function but, in some circumstances, may acquire novel oncogenic functions, namely gain-of-function (GOF), which lead to aberrant cell proliferation, …
Authors
Di Agostino S; Fontemaggi G; Strano S; Blandino G; D’Orazi G
Journal
Journal of Experimental & Clinical Cancer Research, Vol. 38, No. 1,
Publisher
Springer Nature
Publication Date
12 2019
DOI
10.1186/s13046-019-1302-0
ISSN
0392-9078