Developmental Dysplasia of the Hip in Patients with Connective-Tissue Disorders.

» There is a scarcity of literature on the management of hip dysplasia in patients with connective-tissue disorders, including Down syndrome, Marfan syndrome, Ehlers-Danlos syndrome, Larsen syndrome, and osteogenesis imperfecta. » These genetic conditions result in abnormal connective-tissue and ligamentous laxity, and they present a unique, more complex approach for the patient with developmental dysplasia of the hip. » These patients may present at all ages and functional levels on a spectrum of developmental dysplasia of the hip ranging from mild to severe. » Individualized treatment involves consideration of age, disease severity, comorbidities, and functional status. » Treating orthopaedic surgeons may be the first to identify an undiagnosed connective-tissue disorder, and prompt genetic referral is crucial.