Journal article
Atypical Lone Pair–π Interaction with Quinone Methides in a Series of Imido‐Ferrociphenol Anticancer Drug Candidates
Abstract
Ferrociphenols, especially those possessing a heterocycle at the terminus of an aliphatic chain, display strong anticancer activity through a novel redox mechanism that generates active metabolites such as quinone methides (QMs). X-ray crystallography and UV/Vis spectroscopy reveal that the specific lone pair (lp)-π interaction between a carbonyl group of the imide and the quinone motif of the QM plays an important role in the exceptional …
Authors
Wang Y; Pigeon P; Top S; García JS; Troufflard C; Ciofini I; McGlinchey MJ; Jaouen G
Journal
Angewandte Chemie International Edition, Vol. 58, No. 25, pp. 8421–8425
Publisher
Wiley
Publication Date
June 17, 2019
DOI
10.1002/anie.201902456
ISSN
1433-7851