Development of synaptic currents in immobilized muscle of Xenopus laevis.

The effect of chronic immobilization on the development of synaptic currents was studied in myotomal muscle of Xenopus laevis. Embryos and tadpoles were immobilized by rearing them in the presence of tetrodotoxin (TTX) after removal of the egg membranes. Immobilization did not affect the developmental change in duration of miniature end-plate currents (m.e.p.c.s). Rise times decreased from about 3 to 0.6 ms in both immobilized and control …