Journal article
Outcomes Following Macrolide Use in Kidney Transplant Recipients
Abstract
BACKGROUND: Calcineurin inhibitors (CNI; cyclosporine, tacrolimus) are critical for kidney transplant immunosuppression, but have multiple potential drug interactions, such as with macrolide antibiotics. Macrolide antibiotics (clarithromycin, erythromycin, and azithromycin) are often used to treat atypical infections. Clarithromycin and erythromycin inhibit CNI metabolism and increase the risk of CNI nephrotoxicity, while azithromycin does not.
Authors
Jeong R; Quinn RR; Lentine KL; Lloyd A; Ravani P; Hemmelgarn B; Braam B; Garg AX; Wen K; Wong-Chan A
Journal
Canadian Journal of Kidney Health and Disease, Vol. 6, ,
Publisher
SAGE Publications
Publication Date
1 2019
DOI
10.1177/2054358119830706
ISSN
2054-3581