Journal article
Impact of Adopting Population Pharmacokinetics for Tailoring Prophylaxis in Haemophilia A Patients: A Historically Controlled Observational Study
Abstract
BACKGROUND: Performing individual pharmacokinetics (PK) studies in clinical practice can be simplified by adopting population PK-based profiling on limited post-infusion samples. The objective of this study was to assess the impact of population PK in tailoring prophylaxis in patients with haemophilia A.
PATIENTS AND METHODS: Individual weekly treatment plans were developed considering predicted plasma factor activity levels and patients' …
Authors
Stemberger M; Kallenbach F; Schmit E; McEneny-King A; Germini F; Yeung CHT; Edginton AN; von Mackensen S; Kurnik K; Iorio A
Journal
Thrombosis and Haemostasis, Vol. 119, No. 03, pp. 368–376
Publisher
Thieme
Publication Date
March 2019
DOI
10.1055/s-0039-1677700
ISSN
0340-6245