Journal article
Differential Regulation of Components of the Ubiquitin-Proteasome Pathway during Lens Cell Differentiation
Abstract
PURPOSE: To investigate the role for the ubiquitin-proteasome pathway in controlling lens cell proliferation and differentiation and the regulation of the ubiquitin conjugation machinery during the differentiation process.
METHODS: bFGF-induced lens cell proliferation and differentiation was monitored in rat lens epithelial explants by bromodeoxyuridine (BrdU) incorporation and expression of crystallins and other differentiation markers. Levels …
Authors
Guo W; Shang F; Liu Q; Urim L; West-Mays J; Taylor A
Journal
Investigative Ophthalmology & Visual Science, Vol. 45, No. 4, pp. 1194–1201
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Publication Date
April 1, 2004
DOI
10.1167/iovs.03-0830
ISSN
0146-0404
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsBlotting, WesternBromodeoxyuridineCell CycleCell Cycle ProteinsCell DifferentiationCell DivisionCrystallinsCullin ProteinsCyclin-Dependent Kinase Inhibitor p21Cyclin-Dependent Kinase Inhibitor p27CyclinsCysteine EndopeptidasesElectrophoresis, Polyacrylamide GelFibroblast Growth Factor 2Lens, CrystallineMultienzyme ComplexesProtease InhibitorsProteasome Endopeptidase ComplexRabbitsRatsRats, WistarTumor Suppressor ProteinsUbiquitinUbiquitin-Conjugating Enzymes