Whole-Body Hypothermia for Term and Near-Term Newborns With Hypoxic-Ischemic Encephalopathy: A Randomized Controlled Trial

ABSTRACT Hypoxic-ischemic encephalopathy (HIE) in term newborns is an important cause of mortality and long-term sensorineural disabilities. Several studies published in the past 6 years have demonstrated the neuroprotective benefit of therapeutic hypothermia in term neonates born with HIE. Initiating therapeutic hypothermia within 6 hours of birth is considered critical, but few newborns are admitted to tertiary neonatal intensive care units …