Journal article
GRP78 (Glucose-Regulated Protein of 78 kDa) Promotes Cardiomyocyte Growth Through Activation of GATA4 (GATA-Binding Protein 4)
Abstract
The heart manifests hypertrophic growth in response to elevation of afterload pressure. Cardiac myocyte growth involves new protein synthesis and membrane expansion, of which a number of cellular quality control machineries are stimulated to maintain function and homeostasis. The unfolded protein response is potently induced during cardiac hypertrophy to enhance protein-folding capacity and eliminate terminally misfolded proteins. However, …
Authors
Zhang G; Wang X; Bi X; Li C; Deng Y; Al-Hashimi AA; Luo X; Gillette TG; Austin RC; Wang Y
Journal
Hypertension, Vol. 73, No. 2, pp. 390–398
Publisher
Wolters Kluwer
Publication Date
2 2019
DOI
10.1161/hypertensionaha.118.12084
ISSN
0194-911X