Journal article
Two compartment pharmacokinetic model describes the intra‐articular delivery and retention of rhprg4 following ACL transection in the Yucatan mini pig
Abstract
Treatment of the injured joint with rhPRG4 is based on recent observations that inflammation diminishes expression of native PRG4. Re-establishing lubrication between pressurized and sliding cartilage surfaces during locomotion promotes the nascent expression of PRG4 and thus intra-articular (IA) treatment strategies should be supported by pharmacokinetic evidence establishing the residence time of rhPRG4. A total of 21 Yucatan minipigs …
Authors
Hurtig M; Zaghoul I; Sheardown H; Schmidt TA; Liu L; Zhang L; Elsaid KA; Jay GD
Journal
Journal of Orthopaedic Research®, Vol. 37, No. 2, pp. 386–396
Publisher
Wiley
Publication Date
2 2019
DOI
10.1002/jor.24191
ISSN
0736-0266