Journal article
Hemoglobin Hamilton or α2β211(a8)Val→Ile: A silent β‐chain variant detected by triton X‐100 acid‐urea polyacrylamide gel electrophoresis
Abstract
A silent beta-chain hemoglobin variant, not detectable by starch gel or agar gel electrophoresis was found using Triton X-100 acid-urea polyacrylamide gel electrophoresis. The abnormal beta-X chain had a more anodic electrophoretic mobility; 38% of the total beta chain was of the abnormal type. Structural analysis using high-performance liquid chromatography and microsequencing procedures indicated a valine to isoleucine substitution at …
Authors
Wong SC; Ali MAM; Lam H; Webber BB; Wilson JB; Huisman THJ
Journal
American Journal of Hematology, Vol. 16, No. 1, pp. 47–52
Publisher
Wiley
Publication Date
1 1984
DOI
10.1002/ajh.2830160106
ISSN
0361-8609