Journal article
Estimation of amitriptyline and its metabolites in serum and urine by GLC using nitrogen-specific detector
Abstract
1. A gas-chromatographic procedure for the estimation of amitriptyline and its metabolites in serum and urine using a nitrogen-specific detector is described. Specially cleaned glassware and purified solvents are used for the extraction of serum to further minimize extraneous peaks. Trimethylamine is added to serum before extraction to improve the recovery of drugs. Urine is refluxed at pH approximately 1 to hydrolyze the conjugates and to …
Authors
Gupta RN; Molnar G; Hill RE; Gupta ML
Journal
Clinical Biochemistry, Vol. 9, No. 5, pp. 247–251
Publisher
Elsevier
Publication Date
1976
DOI
10.1016/s0009-9120(76)80070-7
ISSN
0009-9120