Journal article
Dual effects of extracellular Ca2+ on cardiotoxin-induced cytotoxicity and cytosolic Ca2+ changes in cultured single cells of rabbit aortic endothelium
Abstract
The effects of extracellular Ca2+ on cytotoxicity induced by cardiotoxin (CTX), isolated from Chinese cobra venom, were investigated in cultured rabbit aortic endothelial cells (RAECs). In Hank's buffered saline solution (HBSS) containing 1.2 mM Ca2+, CTX (1-30 microM) caused cell necrosis and cell death in a concentration-dependent manner, as determined by trypan blue exclusion test performed after a 20-min CTX treatment. The concentration of …
Authors
Ou Y-J; Leung Y-M; Huang S-J; Kwan C-Y
Journal
Biochimica et Biophysica Acta, Vol. 1330, No. 1, pp. 29–38
Publisher
Elsevier
Publication Date
11 1997
DOI
10.1016/s0005-2736(97)00136-3
ISSN
0006-3002