Journal article
Tetrandrine potentiates caffeine-induced contraction but inhibits phenylephrine-induced contraction in perfused rat mesenteric artery
Abstract
Abstract. Effects of tetrandrine (TET), a bisbenzylisoquinoline alkaloid, on the contractile responses of perfused rat mesenteric arteries to phenylephrine (PE) and caffeine were investigated. TET concentration-dependently (1–30 µM) attenuated phenylephrine-induced responses but potentiated the contractile responses to caffeine (5–40 mM) in the presence and absence of Ca2+. Berbamine (BER), a structural analogue of TET, elicited a relatively …
Authors
Kwan C-Y
Journal
Naunyn-Schmiedeberg's Archives of Pharmacology, Vol. 366, No. 6, pp. 613–619
Publisher
Springer Nature
Publication Date
12 2002
DOI
10.1007/s00210-002-0639-6
ISSN
0028-1298