Journal article
Pharmacology of montelukast sodium (Singulair), a potent and selective leukotriene D4 receptor antagonist
Abstract
Montelukast sodium (Singulair), also known as MK-0476 (1-(((1(R)-(3-(2-(7-chloro-2-quinolinyl)-(E)-ethenyl)phenyl)(3-2-(1- hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane) acetic acid sodium salt, is a potent and selective inhibitor of [3H]leukotriene D4 specific binding in guinea pig lung (Ki 0.18 +/- 0.03 nM), sheep lung (Ki 4 nM), and dimethylsulfoxide-differentiated U937 cell plasma membrane preparations (Ki 0.52 +/- 0.23 nM), …
Authors
Jones TR; Labelle M; Belley M; Champion E; Charette L; Evans J; Ford-Hutchinson AW; Gauthier J-Y; Lord A; Masson P
Journal
Canadian Journal of Physiology and Pharmacology, Vol. 73, No. 2, pp. 191–201
Publisher
Canadian Science Publishing
Publication Date
February 1, 1995
DOI
10.1139/y95-028
ISSN
0008-4212