Journal article
Changes in free-calcium levels and pH in synaptosomes during transmitter release
Abstract
The free cytoplasmic Ca2+ concentration [( Ca2+]i) in rat brain synaptosomes estimated by the indicator quin 2 is 104 +/- 8 nM (S.D.) in artificial cerebrospinal fluid (1.2 mM Ca2+), but decreases at lower Ca2+ concentrations in the medium. The presence of quin 2 in the synaptosomes does not affect either the spontaneous release of transmitter (gamma-aminobutyric acid) or the release induced by K+ depolarisation. In quin 2-loaded synaptosomes, …
Authors
Richards CD; Metcalfe JC; Smith GA; Hesketh TR
Journal
Biochimica et Biophysica Acta, Vol. 803, No. 4, pp. 215–220
Publisher
Elsevier
Publication Date
April 1984
DOI
10.1016/0167-4889(84)90110-1
ISSN
0006-3002