Journal article
Real-time in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouse
Abstract
We have used confocal and widefield microscopy to image thrombus formation in real time in the microcirculation of a living mouse. This system provides high-speed, near-simultaneous acquisition of images of multiple fluorescent probes and of a brightfield channel. Vascular injury is induced with a laser focused through the microscope optics. We observed platelet deposition, tissue factor accumulation and fibrin generation after laser-induced …
Authors
Falati S; Gross P; Merrill-Skoloff G; Furie BC; Furie B
Journal
Nature Medicine, Vol. 8, No. 10, pp. 1175–1180
Publisher
Springer Nature
Publication Date
10 2002
DOI
10.1038/nm782
ISSN
1078-8956