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Effects of lorazepam and baclofen on short‐ and...
Journal article

Effects of lorazepam and baclofen on short‐ and long‐latency afferent inhibition

Abstract

KEY POINTS: Short-latency afferent inhibition (SAI) is modulated by GABAA receptor activity, whereas the pharmacological origin of long-latency afferent inhibition remains unknown. This is the first study to report that long-latency afferent inhibition (LAI) is reduced by the GABAA positive allosteric modulator lorazepam, and that both SAI and LAI are not modulated by the GABAB agonist baclofen. These findings advance our understanding of the …

Authors

Turco CV; El‐Sayes J; Locke MB; Chen R; Baker S; Nelson AJ

Journal

The Journal of Physiology, Vol. 596, No. 21, pp. 5267–5280

Publisher

Wiley

Publication Date

11 2018

DOI

10.1113/jp276710

ISSN

0022-3751