Indirect comparison: relative risk fallacies and odds solution

OBJECTIVE: When undertaking indirect comparisons, relative risk (RR) is often suggested as an appropriate indicator of treatment effect, particularly where baseline (common comparator) risks differ. In this article, we demonstrate that such use of RR in indirect comparisons is not necessarily stable with respect to framing of outcomes. STUDY DESIGN AND SETTING: Use of RR is shown to lead to inferential fallacies where, for example, a new …