Journal article
Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins
Abstract
CRISPR-Cas systems are bacterial anti-viral systems, and bacterial viruses (bacteriophages, phages) can carry anti-CRISPR (Acr) proteins to evade that immunity. Acrs can also fine-tune the activity of CRISPR-based genome-editing tools. While Acrs are prevalent in phages capable of lying dormant in a CRISPR-carrying host, their orthologs have been observed only infrequently in virulent phages. Here we identify AcrIIA6, an Acr encoded in 33% of …
Authors
Hynes AP; Rousseau GM; Agudelo D; Goulet A; Amigues B; Loehr J; Romero DA; Fremaux C; Horvath P; Doyon Y
Journal
Nature Communications, Vol. 9, No. 1,
Publisher
Springer Nature
DOI
10.1038/s41467-018-05092-w
ISSN
2041-1723