Mycophenolic acid production in solid-state fermentation using a packed-bed bioreactor

Mycophenolic acid (MPA) was produced from Penicillium brevicompactum by solid-state fermentation (SSF) using pearl barley, and submerged fermentation (SmF) using mannitol. It was found that SSF was superior to SmF in terms of MPA concentration (1219mg/L vs. 60mg/L after 144h fermentation), and the product yields were 6.1mg/g pearl barley for SSF and 1.2mg/g mannitol for SmF. The volumetric productivities were 8.5 and 0.42mg/Lh for SSF and SmF, …