Antibacterial, in vitro antitumor activity and structural studies of rhodium and iridium complexes featuring the two positional isomers of pyridine carbaldehyde picolinic hydrazone ligand

Half-sandwich organometallic rhodium and iridium complexes [1–6] have been synthesized with ligands L1 (L1=Pyridin-2-ylmethylene picolinichydrazine) and L2 (L2=Pyridin-3-ylmethylene picolinichydrazine). Treatment of [{Cp∗MCl2}2] (M=Rh/Ir) with L1 in methanol has yielded mononuclear cationic complexes such as [{Cp∗M(L1N∩N)Cl}]PF6 where {M=Rh (1) and Ir (2)} and dinuclear complexes such as [{(Cp∗MCl)2(L1N∩N, N∩N)}]PF6 where {M=Rh (3) and Ir (4)} …