Journal article
Targeted Inhibition of Serotonin Type 7 (5-HT7) Receptor Function Modulates Immune Responses and Reduces the Severity of Intestinal Inflammation
Abstract
Mucosal inflammation in conditions ranging from infective acute enteritis or colitis to inflammatory bowel disease is accompanied by alteration in serotonin (5-hydroxytryptamine [5-HT]) content in the gut. Recently, we have identified an important role of 5-HT in the pathogenesis of experimental colitis. 5-HT type 7 (5-HT7) receptor is one of the most recently identified members of the 5-HT receptor family, and dendritic cells express this …
Authors
Kim JJ; Bridle BW; Ghia J-E; Wang H; Syed SN; Manocha MM; Rengasamy P; Shajib MS; Wan Y; Hedlund PB
Journal
The Journal of Immunology, Vol. 190, No. 9, pp. 4795–4804
Publisher
Oxford University Press (OUP)
Publication Date
May 1, 2013
DOI
10.4049/jimmunol.1201887
ISSN
0022-1767