Consecutive First-Morning Urine Samples to Measure Change in the Albumin-to-Creatinine Ratio: A Pilot Study of a Home Urine Collection Protocol

BACKGROUND: Multiple first-morning urine samples are recommended for measuring the urine albumin-to-creatinine ratio (ACR); however, this can be challenging in community-based research. METHODS: The objectives of the study are to pilot-test a home urine collection protocol and examine how the average and variance of ACR varied with the number of urine collections and time to laboratory analysis. This is a prospective observational pilot study. …